The antitumor effects of total-flavonoid from Stellera chamaejasmel / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the antitumor effects of total-flavonoid from S. chamaejasmel.</p><p><b>METHOD</b>The in vitro antitumor activity against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma BEL-7402 and leukemia HL-60, were determined by a MTT and clone formation assay. The in vivo antitumor activity was evaluated by the antitumor bioassay against transplanted mouse solid tumor S180 and H22.</p><p><b>RESULT</b>The total-flavonoid inhibited cell proliferation of human tumor cell lines, and its activities are higher than that of vincristine. The total-flavonoid also showed a lower acute toxicity and the strong antitumor activity against transplanted mouse solid tumor S180 and H22 in vivo showing a positive correlation with the concentration. The inhibitory rates at the dose of 0.10 g x kg(-1) ip against S180 and H22 are 45.64% and 47.59%, respectively.</p><p><b>CONCLUSION</b>The total-flavonoid from S. chamaejasme has antitumor activities in vivo and in vitro.</p>