Inclusion constant of beta-CD and paeonol measured by phase solubility method / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>Measure the thermal stability and the forming constant of inclusion complex for paeonol with beta-CD, and investigate interaction between beta-CD and paeonol,</p><p><b>METHOD</b>The thermal stability investigated by using different thermal analysis. The forming constant was determined by using phase method.</p><p><b>RESULT</b>Comparing with melt temperature of paeonol, that of its inclusion complex increase about 220 degrees C. The solubility of paeonol increases with the increased concentration of beta-CD, the composing ratio and the inclusion constant of beta-CD-paeonol is respectively 1/1 and 27.42 mL x mg(-1).</p><p><b>CONCLUSION</b>Inclusion constant is applied to research the stability of included drug in physiological condition.</p>