Study on pharmacokinetics of emodin in Rhizoma Polygontum Cuspidatum and its compound / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 463-465, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-279138
ABSTRACT
<p><b>OBJECTIVE</b>To study the difference in the pharmacokinetics of emodin in Zhiganning capsules and Rhizoma Polygontum Cuspidatum by nonaqueous RP-HPLC.</p><p><b>METHOD</b>The rats were orally administered with the extraction of Rhizoma Polygontum Cuspidatum and Zhiganning capsules. After hydrolysis and extraction, the content of emodin in the plasma is determined by Nonaqueous RP-HPLC.</p><p><b>RESULT</b>The concentration-time profiles of emodin fit two-compartment model. The pharmacokinetics parameters including, t1/2alpha, AUC(0-infinity), CL(s) and C(max) of emodin in the group of Rhizoma Polygontum Cuspidatum were significantly different from these in the group of its compounds.</p><p><b>CONCLUSION</b>There is a significant difference in pharmacokinetics of emodin between zhiganning capsules and the extraction of Rhizoma Polygontum Cuspidatum.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Capsules
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Emodin
/
Rats, Sprague-Dawley
/
Area Under Curve
/
Polygonum
/
Rhizome
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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