Studies on the anticancer effects of total alkaloid from Viscum coloratum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 381-387, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-279156
ABSTRACT
<p><b>OBJECTIVE</b>To study the anticancer effects of total alkaloid from Viscum coloratum in vivo and vitro.</p><p><b>METHOD</b>In vitro, MTT assays were used t o measure the inhibitory effect. Cells at period of logarithmic growth were incubated for 24 hours. Then total alkaloid of various concentrations were added. 24 hours later, supernatant was removed and MTT was added. 4 hours after that, DMSO was added, then 30 minutes later, A value was measured. In vivo, suspension of carcinoma cells was implanted in the mice's limbs subcutaneously, 0.2mL each. 24 hours later, the mice were grouped randomly. Fed by total alkaloid continuously for 7 days, the mice were sacrificed. The tumors were weighed and calculated the inhibitory rates.</p><p><b>RESULT</b>In vitro, it shows that total alkaloid has prominent inhibitory effect on the growth of carcinoma cells. In vivo, it shows that total alkaloid can inhibit the growth of tumors and prolong the survival days of the mice bearing tumors.</p><p><b>CONCLUSION</b>Total alkaloid from Viscum coloratum has the activities of anticancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Breast Neoplasms
/
Esophageal Neoplasms
/
Chemistry
/
Viscum
/
Cell Line, Tumor
/
Cell Proliferation
/
Drug Therapy
Limits:
Animals
/
Female
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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