Chemical constituents from marine alga Chaetomorpha basiretorsa / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 347-350, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-279166
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of marine alga Chaetomorpha basiretorsa.</p><p><b>METHOD</b>Compounds were isolated by normal phase silica gel and Sephadex LH-20 gel colum chromatography, reverse phase MPLC, reverse phase HPLC and recrystallization. Their structures were elucidated by spectroscopic methods including MS, IR, NMR, and X-ray crystalography. Cytotoxicity of the compounds were screened by using standard MTT method.</p><p><b>RESULT</b>Nine compounds were isolated from C. basiretorsa and their structures were identified as N-phenyl-2-naphthalenamine( I ), dibutyl phthalate( II ), diisobutyl phthalate( III ), 1-phenyl-ethane-1, 2-diol( IV ), 2-hydrox-gamma-benzaldehyde( V ), diethyleneglycol monobenzoate( VI ), uracil( VII ), thymine( VIII ) and thymidine( IX ).</p><p><b>CONCLUSION</b>All these compounds were obtained from this genus for the first time, N-phenyl-2-naphthalenamine and diethyleneglycol monobenzoate were first reported from the marine organisms. Compound I and VII showed moderate activity against KB cell(IC50 10.15 microg x mL(-1) for I and 3.79 microg x mL(-1) for VII ) and MCF-7 cell(IC50 3.24 microg x mL(-1) for VII).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Uracil
/
KB Cells
/
Chemistry
/
Crystallization
/
Chlorophyta
/
1-Naphthylamine
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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