Study of diffusion of muscone in different inclusion complexes and liposome through mouse (correction of rat) skin in vitro / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the penetrating rate of muscone in different inclusion complexes and liposome.</p><p><b>METHOD</b>The transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on mouse [corrected] skin with 40% EtOH as the absorption solution and with an improved Franz diffuse cell.</p><p><b>RESULT</b>Among the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-beta-cyclodextrin inclusion and the liposome were higher than muscone, and that of muscone in the beta-cyclodextrin inclusion is the lowest.</p><p><b>CONCLUSION</b>The HP-beta-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.</p>