Effect of ginsenoside total saponinon on regulation of P450 of livers of rats after γ-ray irradiation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4037-4043, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-279288
ABSTRACT
Effect of ginsenoside total saponin (GTS) on the regulation of P450 of livers of rats after γ-ray irradiation was studied. Rats were irradiated by the ⁶⁰Coγ-ray for one-time dose of 5.5 Gy, dose rate of 117.1-119.2 cGy. The cocktail probe, qPCR and Western blot were used to detect expression of enzymatic activites, mRNA and protein of rats. Contrasted with blank group, expression of CYP1A2, 2B1, 2E1, 3A4 of irradiation group showed a up-regulated (P < 0.05). Contrasted with irradiation group, exprression of CYP1A2, 2B1, 2E1, 3A4 of GTS group showed a downward trend. GTS had negative agonistic action against expression of P450 of rats by irradiatied.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Radiation Effects
/
Microsomes, Liver
/
Drugs, Chinese Herbal
/
Chemistry
/
Rats, Wistar
/
Cytochrome P-450 Enzyme System
/
Ginsenosides
/
Gamma Rays
/
Genetics
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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