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Protective effects of paraventricular nucleus stimulation and vasopressin on gastric ischemia-reperfusion injury in rats / 生理学报
Acta Physiologica Sinica ; (6): 133-138, 2002.
Article in Chinese | WPRIM | ID: wpr-279324
ABSTRACT
The effects of paraventricular nucleus (PVN) stimulation and vasopressin on gastric ischemia-reperfusion injury (GI-RI) were investigated in male SD rats of which the celiac artery was clamped for 30 min and reperfused for 1 h by removal of the clamp. The results were as follows. Both electrical and chemical stimulation of the PVN obviously attenuated the GI-RI. Bilateral electrolytic lesion of the nucleus tractus solitarius (NTS) or microinjection of AVP-V(1) receptor antagonist into the NTS could eliminate the protective effect of electrical stimulation of the PVN on GI-RI. Hypophysectomy did not influence the effect of electrical stimulation of the PVN. Both vagotomy and sympathectomy could increase the effect of stimulating PVN on GI-RI. Microinjection of arginine-vasopressin (AVP) into the PVN also attenuated the effect on GI-RI. These results suggest that the PVN and AVP participate in the regulation of GI-RI and play an important role in protection against GI-RI. This protective effect of PVN on GI-RI might be mediated by activation of AVP-ergic neurons in the PVN, which release AVP from the descending projection fibers and activate the AVP-V(1) receptors on the NTS neurons. The vagus and sympathetic nerves are involved in the efferent pathway exerting their effects on GI-RI. Hypophysis does not seem to be involved in the protective effect of PVN stimulation.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Paraventricular Hypothalamic Nucleus / Pharmacology / Physiology / Stimulation, Chemical / Stomach / Sympathetic Nervous System / Therapeutics / Vagus Nerve / Vasopressins / Reperfusion Injury Limits: Animals Language: Chinese Journal: Acta Physiologica Sinica Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Paraventricular Hypothalamic Nucleus / Pharmacology / Physiology / Stimulation, Chemical / Stomach / Sympathetic Nervous System / Therapeutics / Vagus Nerve / Vasopressins / Reperfusion Injury Limits: Animals Language: Chinese Journal: Acta Physiologica Sinica Year: 2002 Type: Article