Active compounds from rhizomes of Musa basjoo / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2424-2427, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-279428
ABSTRACT
<p><b>OBJECTIVE</b>To study the active compounds from the rhizomes of Musa basjoo.</p><p><b>METHOD</b>Antioxidant and alpha-glucosidase inhibitory activity of different extracts were tested. Using bioassay-guided fractionation, the chemical constituents in EtOAC extracts were isolated by column chromatography and identified by MS and NMR spectroscopy.</p><p><b>RESULT</b>Five compounds were isolated and identified as 2',3, 4'-trihydroxyflavone (1), 3,3'-bis-hydroxyanigorufone (2), irenolone (3), 4-dihydroxy-9-(4'-hydroxyphenyl)-phenalenone (4) and 3,4-dihydroxybenzaldehyde (5). Compound 1(IC50 8.61 mg x L(-1)), 3 (IC50 19.55 mg x L(-1)) and 5 (IC50 1.1 mg x L(-1)) had antioxidant activity. Compound 2 (IC50 24.15 mg x L(-1)) and 4(IC50 2.81 mg x L(-1)) had alpha-glucosidase inhibitory activity. Compound 5 showed MIC of 0.078, 0.313, 0.039 microg/disc against SA, MRSA and ESBLs, respectively.</p><p><b>CONCLUSION</b>Compound 1-5 were isolated from this plant for the first time. Compound 5 was isolated from the genus Musa for the first time. All compound except 5 were first reported about activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Staphylococcus aureus
/
Bacterial Proteins
/
Plant Extracts
/
Chemistry
/
Musa
/
Rhizome
/
Enzyme Inhibitors
/
Alpha-Glucosidases
/
Glycoside Hydrolase Inhibitors
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
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