The incidence of pelvic and para-aortic lymph node metastasis in uterine papillary serous and clear cell carcinoma according to the SEER registry / 부인종양
Journal of Gynecologic Oncology
;
: 19-24, 2015.
Article
in English
| WPRIM
| ID: wpr-27946
ABSTRACT
OBJECTIVE:
In this study we utilized the Surveillance, Epidemiology and End-Results (SEER) registry to identify risk factors for lymphatic spread and determine the incidence of pelvic and para-aortic lymph node metastases in patients with uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCCC) who underwent complete surgical staging and lymph node dissection.METHODS:
Nine hundred seventy-two eligible patients diagnosed between 1998 to 2009 with International Federation of Gynecology and Obstetrics (FIGO) 1988 stage IA-IVA UPSC (n=685) or UCCC (n=287) were identified for analysis. Binomial logistic regression was used to determine risk factors for lymph node metastasis, with the incidence of pelvic and para-aortic lymph node metastases reported for each FIGO primary tumor stage. The Cox proportional hazards regression model was used to determine factors associated with overall survival.RESULTS:
FIGO primary tumor stage was the only independent risk factor for lymph node metastasis (p60 years (HR, 1.70; 95% CI, 1.21 to 2.41; p<0.01), and advanced FIGO primary tumor stage (p<0.01). Tumor grade, histologic subtype, and patient race did not predict for either lymph node metastasis or overall survival.CONCLUSION:
There is a high incidence of both pelvic and para-aortic lymph node metastases for FIGO stages IC and above uterine papillary serous and clear cell carcinomas, suggesting a potential role for lymph node-directed therapy for these patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Abdominal
/
Pelvis
/
United States
/
Uterine Neoplasms
/
Incidence
/
Cystadenocarcinoma, Serous
/
Cystadenocarcinoma, Papillary
/
Adenocarcinoma, Clear Cell
/
SEER Program
/
Kaplan-Meier Estimate
Type of study:
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2015
Type:
Article
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