Therapeutic effect of levamisole plus HBV vaccine and dipyridamole on patients chronically infected by HBV with precore mutation / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 284-286, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-279553
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the incidence of precore mutation in HBeAg negative HBV infected patients and the therapeutic effect of the immune therapy (levamisole + HBV vaccine + dipyridamole) on patients chronically infected by HBV with precore mutation.</p><p><b>METHODS</b>The precore region of HBV from the HBeAg (-) chronic hepatitis patients was sequenced and the patients suffered from HBV with precore mutation were treated with immune therapy.</p><p><b>RESULTS</b>The precore mutation rate was 10/12. The therapeutic effect of the immune therapy on the precore mutation patients (5/7) was better than that on the HBsAg(+), HBeAg(+) patients (2/11), P less than 0.05.</p><p><b>CONCLUSION</b>The precore mutation rate was quite high in the HBsAg(+), HBeAg(-) patients we studied. The immune-therapy has some therapeutic effects on the patients with precore mutation. But the number of cases was too small, further study is needed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Virology
/
Blood
/
DNA, Viral
/
Hepatitis B virus
/
Levamisole
/
Hepatitis B Vaccines
/
Combined Modality Therapy
/
Lamivudine
/
Hepatitis B, Chronic
Limits:
Adolescent
/
Adult
/
Child
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2004
Type:
Article
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