Effects of exogenous IL-10 on IL-6 and ICAM-1 expression in inflammatory gingival tissue / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>This study aimed at investigating effects of exogenous interleukine-10 (IL-10) on IL-6 and intercellular adhesion molecular (ICAM-1) expression in inflamed gingival tissue.</p><p><b>METHODS</b>The expression of IL-6 and ICAM-1 was examined using immunohistochemical techniques. Inflammatory gingival tissue treated with IL-10 was taken as the experimental group and the same patient's inflammatory gingival tissue without treatment of IL-10 was included into the control group.</p><p><b>RESULTS</b>IL-6 expression was found mainly in monocytes, macrophages, lymphocytes, endotheliocytes and fibroblasts. The expression of ICAM-1 was found mainly in epithelial cells, monocot-macrophages, lymphocytes, endotheliocytes and fibroblasts. The immunohistochemical optical density (IOD) of the expression of IL-6 and ICAM-1 was detected by using Image-Proplus software, and the results showed that the expression in the experimental group differed significantly from that in the control group.</p><p><b>CONCLUSION</b>The exogenous IL-10 may down-regulate IL-6 and ICAM-1 expression in inflammatory gingival tissue.</p>