A fundamental study on bioreactions of Sr-HA / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 172-183, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-279640
ABSTRACT
<p><b>OBJECTIVE</b>Sr-HA, a new type of hydroxyapatite biomaterial, was implanted into animals to study the bioreaction and character, which would be helpful for the further clinical applications in the future.</p><p><b>METHODS</b>Totally 24 rabbits were divided into 3 groups. The bone defect of 6 mm x 12 mm x 4 mm was made at both mandibular angles of rabbits and Sr-HA of different proportion (10%, 5%, 0) was applied to reform the defects. One group of animals were killed randomly at 1, 3 and 6 months after operation to evaluate the material biological compatibility using anatomic, X-ray examination, histological and ECT methods.</p><p><b>RESULTS</b>The histological photographs showed that Sr-HA caused little infection around implanted area and, almost was not repulsed by hosts. With the degradation of biomaterial, there was more apparent new bone growth in the area around Sr-HA than that around HA and some ossification can be found in soft tissue nearby. Also a tight osteointegrity was gradually got after the operation, according to the results of X-ray and, the border between Sr-HA and bone was hardly discovered at the 6th month after the operation. A more obvious nuclide assembling was observed at the side of Sr-HA by ECT images. With the biodegradation of Sr-HA, more new bone was intruded into the spare space of the biomaterial.</p><p><b>CONCLUSION</b>Sr-HA has better biocompatibility and higher biodegradation than that of pure HA. It holds an excellent osteoinductivity and fair osteoconductivity to some degree too. So a more satisfying effect of bone defect rehabilitation was gained with the increasing new bone depositing in the free space of the material, when it degraded gradually.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Pharmacology
/
Physiology
/
Strontium
/
General Surgery
/
Biocompatible Materials
/
Biodegradation, Environmental
/
Chemistry
/
Bone Substitutes
/
Implants, Experimental
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2002
Type:
Article
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