Dynamic expression of PD-1 in HBV-specific cytotoxic T lymphocytes correlates with memory T-cell development in acute hepatitis B patients / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 649-653, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-279714
ABSTRACT
<p><b>OBJECTIVES</b>Programmed death-1 (PD-1) up-regulation impairs virus-specific CD8+ T-cell responses during chronic viral infection. Whether PD-1 expression influences the virus-specific CD8+ T cells in humans with acute viral infection remains largely undefined. This study aims to characterize the PD-1 expression during acute hepatitis B (AHB), and further addresses the association between the PD-1 dynamics and memory T-cell formation during acute HBV infection.</p><p><b>METHODS</b>Peripheral HBV-specific CD8+ T cells from 11 HLA-A2-positive AHB patients were longitudinally quantitatively analyzed, and PD-1, memory markers CCR7, CD45RA and CD127 and activation marker CD38 on HBV-specific CD8+ T cells were measured using flow cytometric assay. Serum ALT, HBsAg, HBsAb and HBV-DNA levels were evaluated for each subject.</p><p><b>RESULTS</b>All 11 AHB patients examined had multiple pentamer-positive CD8+ T-cell responses in their early phase of HBV infection. Specifically, their PD-1 on pentamer-positive CD8+ T-cells was significantly up-regulated at the onset of their disease. Following their disease resolution, the dynamic decrease in PD-1 expression was found to correlate with the phenotypic development of memory CD8+ T cells, indicated by the increases in CCR7, CD45RA and CD127 and decrease in CD38.</p><p><b>CONCLUSION</b>PD-1-mediated negative signaling may be closely associated with memory T-cell formation during acute self-limited hepatitis B.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes, Cytotoxic
/
Antigens, CD
/
Acute Disease
/
Allergy and Immunology
/
Apoptosis Regulatory Proteins
/
Programmed Cell Death 1 Receptor
/
Hepatitis B
/
Immunologic Memory
/
Metabolism
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2008
Type:
Article
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