Clinical Significance of Focal Breast Lesions Incidentally Identified by 18F-FDG PET/CT / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
;
: 456-463, 2008.
Article
in Korean
| WPRIM
| ID: wpr-27986
ABSTRACT
PURPOSE:
We evaluated the incidence and malignant risk of focal breast lesions incidentally detected by 18F-FDG PET/CT. Various PET/CT findings of the breast lesions were also analyzed to improve the differentiation between benign from malignant focal breast lesions. MATERIALS ANDMETHODS:
The subjects were 3,768 consecutive 18F-FDG PET/CT exams performed in adult females without a history of breast cancer. A focal breast lesion was defined as a focal 18F-FDG uptake or a focal nodular lesion on CT image irrespective of 18F-FDG uptake in the breasts. The maximum SUV and CT pattern of focal breast lesions were evaluated, and were compared with final diagnosis.RESULTS:
The incidence of focal breast lesions on PET/CT in adult female subjects was 1.4% (58 lesions in 53 subjects). In finally confirmed 53 lesions of 48 subjects, 11 lesions of 8 subjects (20.8%) were proven to be malignant. When the PET/CT patterns suggesting benignancy (maximum attenuation value > 75 HU or 20) were added as diagnostic criteria of PET/CT to differentiate benign from malignant breast lesions along with maximum SUV, the area under ROC curve of PET/CT was significantly increased compared with maximum SUV alone (0.680+/-0.093 vs. 0.786+/-0.076, p<0.05).CONCLUSION:
The malignant risk of focal breast lesions incidentally found on 18F-FDG PET/CT is not low, deserving further diagnostic confirmation. Image interpretation considering both 18F-FDG uptake and PET/CT pattern may be helpful to improve the differentiation from malignant and benign focal breast lesion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Neoplasms
/
Incidence
/
ROC Curve
/
Fluorodeoxyglucose F18
/
Early Detection of Cancer
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
/
Screening study
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
Nuclear Medicine and Molecular Imaging
Year:
2008
Type:
Article
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