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Significance of Th17/Treg imbalance in children with primary immune thrombocytopenia / 中国当代儿科杂志
Article in Chinese | WPRIM | ID: wpr-279864
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the significance of Th17/Treg imbalance in the development and treatment of primary immune thrombocytopenia (ITP) in children.</p><p><b>METHODS</b>Thirty-two children diagnosed with ITP between May and August, 2015 and 22 healthy children were enrolled. Flow cytometry was used to determine the Th17/Treg ratio in peripheral blood of healthy children and children with ITP before and after treatment with immunoglobulin.</p><p><b>RESULTS</b>Compared with the patients with ITP before treatment, the healthy children and the patients treated with immunoglobulin had a significantly lower percentage of Th17 cells in CD4+ T cells, a significantly lower Th17/Treg ratio, and a significantly higher percentage of Treg cells in CD4+ T cells in peripheral blood (P<0.05). In the 32 ITP children treated with immunoglobulin, 20 had complete response, 4 had response, and 8 had no response. The patients with complete response had a significantly lower percentage of Th17 cells in CD4+ T cells and a significantly lower Th17/Treg ratio in peripheral blood than the patients without response (P<0.05).</p><p><b>CONCLUSIONS</b>The Th17/Treg imbalance can be found in children with ITP. Immunoglobulin can improve the cellular immune function by regulation of the Th17/Treg ratio. The Th17/Treg ratio may serve as an indicator for assessing the therapeutic effects of ITP.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Female / Humans / Male / Child / Child, Preschool / Purpura, Thrombocytopenic, Idiopathic / T-Lymphocytes, Regulatory / Allergy and Immunology / Th17 Cells / Infant Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Female / Humans / Male / Child / Child, Preschool / Purpura, Thrombocytopenic, Idiopathic / T-Lymphocytes, Regulatory / Allergy and Immunology / Th17 Cells / Infant Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2016 Type: Article