Risk factors for hearing impairment induced by cytomegalovirus infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 224-228, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-279867
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the risk factors for hearing impairment induced by cytomegalovirus (CMV) infection in children.</p><p><b>METHODS</b>One hundred and fifty-eight children diagnosed with CMV infection were enrolled as subjects. Based on the results of the brainstem auditory evoked potential (BAEP) test, patients were classified into normal hearing group (n=117; BAEP≤35) and abnormal hearing group (n=41; BAEP>35). A retrospective analysis was performed on the general information, routine blood indices, liver function, copy number of CMV-DNA in urine and breast milk. The receiver operating characteristic (ROC) curve was used to predict the copy number of CMV-DNA resulting in abnormal BAEP. The Spearman rank correlation analysis was used to test the correlations of the copy number of CMV-DNA in urine with the degree of hearing impairment and platelet count.</p><p><b>RESULTS</b>The incidence rates of platelet abnormality and abnormal liver function and the copy number of CMV-DNA in urine were significantly higher in the abnormal hearing group than in the normal hearing group (P<0.01). According to the ROC curve, the copy number of CMV-DNA in urine had a sensitivity of 46.3% and a specificity of 93.2% in predicting hearing impairment when it reached 1.415×10(6) per mL. The results of correlation analysis showed that the degree of hearing impairment was positively correlated with the copy number of CMV-DNA (r=0.382, P<0.01); the platelet count was negatively correlated with the copy number of CMV-DNA in urine (r=-0.233, P=0.003).</p><p><b>CONCLUSIONS</b>An increased copy number of CMV-DNA in urine might be a risk factor for hearing impairment induced by CMV infection. Children are likely to have hearing impairment when the copy number of CMV-DNA reaches 1.415×10(6) per mL. The monitoring of hearing should be strengthened in CMV-infected children with a decreased platelet count.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Urine
/
DNA, Viral
/
Retrospective Studies
/
Risk Factors
/
ROC Curve
/
Evoked Potentials, Auditory, Brain Stem
/
Cytomegalovirus Infections
/
Hearing Loss
Type of study:
Etiology study
/
Observational study
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Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article
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