Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 61-66, 2016.
Article
in Zh
| WPRIM
| ID: wpr-279896
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins.</p><p><b>METHODS</b>A total of 147 pairs of twins (47 pairs of monozygotic twins, 100 pairs of dizygotic twins) aged 8-12 years from Baotou and Hohhot were selected as respondents. The Achenbach Child Behavior Checklist (CBCL) was used to calculate the scores of anxiety-depression factors in school-aged twins. The DNA was extracted from oral epithelial cells, and polymerase chain reaction was applied for 5-HTTLPR genotyping. The generalized estimating equation (GEE) was used to analyze the effect of 5-HTTLPR polymorphism and family environment on anxiety-depression in school-aged twins.</p><p><b>RESULTS</b>The children with LS and SS genotypes had significantly higher scores of anxiety-depression factors than those with LL genotype (χ2=3.938, P<0.05). The interaction of 5-HTTLPR genotype with family cohesion and family rearing patterns had a significant impact on the scores of anxiety-depression factors in twins (χ2=6.129 and 7.665, both P<0.05).</p><p><b>CONCLUSIONS</b>5-HTTLPR genotype is significantly correlated with the scores of anxiety-depression factors in school-aged twins. In the family with high cohesion and an autocratic family rearing pattern, S allele may increase the possibility of anxiety-depression in twin children.</p>
Full text:
1
Index:
WPRIM
Main subject:
Anxiety
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Polymorphism, Genetic
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Twins
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Depression
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Serotonin Plasma Membrane Transport Proteins
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Genetics
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Genotype
Limits:
Child
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article