Diagnostic values of urinary netrin-1 and kidney injury molecule-1 for acute kidney injury induced by neonatal asphyxia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 24-28, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-279903
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the values of urinary netrin-1 and kidney injury molecule-1 (KIM-1) in the early diagnosis of acute kidney injury (AKI) induced by neonatal asphyxia.</p><p><b>METHODS</b>A total of 80 full-term neonates with asphyxia were enrolled (mild asphyxia 34 neonates; severe asphyxia 46 neonates). Forty normal full-term neonates were selected as the control group. Urinary samples were collected from the neonates in the three groups within 12 hours and 13-48 hours after birth. ELISA was applied to measure urinary levels of netrin-1 and KIM-1. Peripheral venous blood samples were also collected to measure serum creatinine (Scr) level.</p><p><b>RESULTS</b>Compared with the control group, the asphyxia group had significantly higher urinary levels of netrin-1 and KIM-1 within 48 hours after birth and a significantly higher Scr level within 13-48 hours after birth (P<0.05). The neonates in the AKI group had significantly higher urinary levels of netrin-1 and KIM-1 and Scr level within 48 hours after birth than those in the non-AKI group (P<0.05). The areas under the receiver operating characteristic curve for urinary netrin-1 and KIM-1 levels within 12 hours after birth to predict AKI after asphyxia were 0.878 (95% CI 0.775-0.981; P<0.01) and 0.899 (95% CI 0.829-0.969; P<0.01), respectively. Any two indicators of urinary netrin-1 level, urinary KIM-1 level, and Scr level within 12 hours after neonatal asphyxia had a positive correlation (P<0.05).</p><p><b>CONCLUSIONS</b>Urinary netrin-1 and KIM-1 levels increase significantly when neonates with asphyxia develop AKI. Urinary netrin-1 and KIM-1 can be used as indicators for the early diagnosis of AKI after asphyxia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, Virus
/
Asphyxia Neonatorum
/
Urine
/
Membrane Glycoproteins
/
Tumor Suppressor Proteins
/
Diagnosis
/
Acute Kidney Injury
/
Hepatitis A Virus Cellular Receptor 1
/
Netrin-1
/
Nerve Growth Factors
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article
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