Effects of HPGA suppression on predicted adult height in girls with central precocious puberty / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between the suppression of the hypothalamic-pituitary-gonadal axis (HPGA) and the predicted adult height (PAH) in girls with central precocious puberty (CPP) during the treatment with gonadotropin-releasing hormone analogue (GnRHa), in order to provide guidance for individualized GnRHa dose adjustment in clinical practice.</p><p><b>METHODS</b>The clinical data of 75 CPP girls were collected, and then height, bone age (BA), uterine and ovarian volumes, and peak luteinizing hormone (LH), peak follicle-stimulating hormone (FSH), and estradiol (E2) levels were recorded at different time points of GnRHa treatment. PAH at each time point was calculated. PAH improvement (&Delta;PAH=PAH-target height) and its relationship with the degree of HPGA suppression were analyzed. Threshold effect analysis was applied to determine the best HPGA suppression range for&Delta;PAH.</p><p><b>RESULTS</b>After GnRHa treatment, PAHs were improved markedly compared with the data in the early stage of treatment. &Delta;PAH showed a negative correlation with &Delta;BA. At 24 months of treatment, &Delta;PAH was also negatively correlated with LH. Uterine volume controlled between 2.3 and 3.0 mL, LH level controlled below 0.8 IU/L, and FSH controlled below 2.4 IU/L could slow down the growth of BA and improve PAH.</p><p><b>CONCLUSIONS</b>GnRHa treatment can improve the PAH of CPP girls. Selection of an appropriate therapeutic dose for GnRHa to control uterine volume, LH and FSH levels within certain ranges can slow down the growth of BA and improve PAH.</p>