Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 533-536, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-280008
ABSTRACT
<p><b>OBJECTIVE</b>To identify polymorphisms of the serotonin transporter(5-HTT) gene and to find out whether there was relationship between any such polymorphisms and sleep apnea syndrome (SAS).</p><p><b>METHODS</b>For two polymorphisms of 5-HTT target DNA gene was amplified using polymerase chain reaction (PCR) and 6% non-denaturing polyacrylamide gels electrophoresis. The frequencies of the different forms of the genotypes and alleles of 5-HTT gene were analyzed in 104 patients with SAS and 150 healthy controls.</p><p><b>RESULTS</b>The frequencies of the S or L alleles and the S/S, S/L or L/L genotypes in promoter region of 5-HTT gene in SAS group were not significantly different to those in healthy controls (P > 0.05). However, the frequencies of 10/10, 12/10 genotypes of 5-HTT-VNTR in SAS patients were significantly higher than those in healthy control subjects (P < 0.05). Moreover, the frequency of the allele 10 of 5-HTT-VNTR in SAS patients was significantly higher than that in healthy controls (P<0.01).</p><p><b>CONCLUSION</b>The allele 10 of 5-HTT-VNTR might be a susceptible factor in the pathogenesis of SAS.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Sleep Apnea Syndromes
/
Polymerase Chain Reaction
/
Promoter Regions, Genetic
/
Minisatellite Repeats
/
Genetic Predisposition to Disease
/
Alleles
/
Serotonin Plasma Membrane Transport Proteins
/
Gene Frequency
/
Genetics
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2005
Type:
Article
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