Polymorphisms within the interferon-Gamma receptor associated with systemic lupus erythematosus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 320-323, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-280060
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between polymorphisms within the interferon-Gamma receptor gene(IFN-GammaR) and systemic lupus erythematosus (SLE) in Chinese people.</p><p><b>METHODS</b>The IFN-GammaR genotypes of 94 SLE patients and 80 healthy subjects were examined by the reverse transcription-polymerase chain reaction (RT-PCR)-single-strand conformation polymorphism (SSCP) method, RT-PCR-restriction fragment length polymorphism (RFLP) method and DNA sequencing.</p><p><b>RESULTS</b>There was no statistically significant difference in the IFN-GammaR genotype frequencies between the two groups. The IFN-Gamma R2 Arg64/Arg64 genotype decreased the risk of SLE (OR = 2.481, 95% CI 0.992 - 6.203, P = 0.047). The decreased risk of the development of SLE was detected in the individuals who had the combination of IFN-GammaR2 Arg64/Arg64 genotype and IFN-GammaR1 Val14/Val14 genotype (OR = 2.481, 95% CI 0.992 - 6.203, P = 0.047).</p><p><b>CONCLUSION</b>The IFN-GammaR2 Arg64/Arg64 genotype does not determine susceptibility to SLE in Chinese people, and the combination of IFN-Gamma R2 Arg64/Arg64 genotype and IFN-Gamma R1 Val14/Val14 genotype does not, either.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Base Sequence
/
Sequence Analysis, DNA
/
Receptors, Interferon
/
Polymorphism, Single-Stranded Conformational
/
Genetic Predisposition to Disease
/
Reverse Transcriptase Polymerase Chain Reaction
/
Genetics
/
Genotype
/
Lupus Erythematosus, Systemic
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2005
Type:
Article
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