Study of relations between matrix metalloproteinase-9 polymorphism (C-1562T) and acute coronary syndrome in Han population of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 313-316, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-280062
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between acute coronary syndrome (ACS) and functional matrix metalloproteinase-9 polymorphism (C-1562-T).</p><p><b>METHODS</b>This study was conducted with a case-control design including 101 patients with angiographically documented ACS and 105 control subjects who were free from coronary artery disease and had normal angiograms. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for the common C-1562-T functional promoter polymorphism of the MMP-9 gene.The relationship between the polymorphism in the MMP-9 gene and the severity of coronary arterial stenosis was analyzed.</p><p><b>RESULTS</b>The results of individual polymorphisms analysis showed that the frequency of C/T and T/T genotypes of the C-1562-T polymorphism (27.2%) in patients with ACS was significantly higher than that in those with a normal angiogram (13.34%).The frequencies of -1562T allele were 14.9% and 7.2% in ACS group and control group respectively (Chi2 = 5.617, P = 0.018). The frequencies of C/T and T/T genotypes of the C-1562-T polymorphism were not statistically different among ACS patients with normal and one,two,three or more significantly diseased vessels (Chi2 = 0.601, P = 0.896).</p><p><b>CONCLUSION</b>The present findings suggest that the genetic polymorphism in MMP-9 promoter (C-1562-T) is associated with the susceptibility to ACS in the Han population of China. And the C-1562-T polymorphism may not be useful as a predictor of the severity of coronary atherosclerosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Base Sequence
/
China
/
Polymerase Chain Reaction
/
Promoter Regions, Genetic
/
Sequence Analysis, DNA
/
Genetic Predisposition to Disease
/
Matrix Metalloproteinase 9
/
Polymorphism, Single Nucleotide
/
Asian People
/
Ethnology
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2005
Type:
Article
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