P53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer: a meta-analysis / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relation between p53 protein expression and chemosensitivity to cisplatin in patients with non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>The DerSimonian-Laird random effect model was used to analyze the data reported in relevant literature.</p><p><b>RESULTS</b>Sixteen trials involving 1070 patients were retrieved. The overall positivity rate of p53 was 50.4% and overall response rate to cisplatin was 38.7%. The test for heterogeneity showed that all eligible studies had heterogeneity (chi 2-/+47.57, P<0.0001). The combined odds ratio (OR) was 1.37, with 95% confidence interval of 0.84-2.24.</p><p><b>CONCLUSION</b>Expression of p53 protein in patients with NSCLC is not associated with the chemosensitivity to cisplatin.</p>