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Mutations of HBV polymerase gene sequence in lamivudine-resistant chronic hepatitis B patients / 南方医科大学学报
Journal of Southern Medical University ; (12): 729-730, 2008.
Article in Chinese | WPRIM | ID: wpr-280109
ABSTRACT
<p><b>OBJECTIVE</b>To explore the characteristics of mutation in HBV polymerase (P) gene reverse transcriptase region (RT region) in lamivudine-resistant chronic hepatitis B (CHB) patients.</p><p><b>METHODS</b>This study involved 115 CHB patients who developed clinical resistance to lamivudine. Direct sequencing of the PCR products was used to detect lamivudine genotypic resistance.</p><p><b>RESULTS</b>Lamivudine resistant mutation was detected in 103 patients, and the major mutations included rtL180M+rtM204V and rtM204I, accounting for 58.3% and 22.3%, respectively. Other resistant substitutions included rtL80V/I, rtT184S, and rtA200V, and combined mutation of triple resistant substitutions was detected in HBV RT region of 5 patients by direct sequencing.</p><p><b>CONCLUSION</b>For lamivudine-treated patients, combined mutation at the sites other than rtL180 and rtM204 in HBV P gene should also be detected for drug resistance evaluation.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Virology / Gene Products, pol / Hepatitis B virus / Lamivudine / Anti-HIV Agents / Hepatitis B, Chronic / Drug Resistance, Viral / Therapeutic Uses / Drug Therapy / Genetics Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Virology / Gene Products, pol / Hepatitis B virus / Lamivudine / Anti-HIV Agents / Hepatitis B, Chronic / Drug Resistance, Viral / Therapeutic Uses / Drug Therapy / Genetics Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2008 Type: Article