An experimental study on the cytokine expression of macrophage influenced by biomaterials / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 105-109, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-280253
ABSTRACT
This experiment was designed to investigate the influence of two biomaterials, titanium oxide (Ti-O) and stainless steel (SS), on the cytokine expression of macrophage, and further, to evaluate their biocompatibility. After being co-cultured with Ti-O and SS for 72 h, the cell number and morphology of macrophages attached on materials were detected by fluorescent microscope and SEM. Nitride oxide (NO) and monocyte chemoattractant protein 1 (MCP-1) released by the macrophages co-cultured with different materials were also examined and compared. We found that the cell number of macrophages attached to Ti-O was smaller than that attached to SS. The levels of NO and MCP-1 released by the macrophages co-cultured with Ti-O were lower when compared with those released by macrophages co-cultured with SS. These results demonstrate that Ti-O has better biocompatibility than does SS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Stainless Steel
/
Titanium
/
Biocompatible Materials
/
Materials Testing
/
Cells, Cultured
/
Rats, Sprague-Dawley
/
Chemokine CCL2
/
Cell Biology
/
Macrophages
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2009
Type:
Article
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