Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection? / 病毒学报
Chinese Journal of Virology
;
(6): 450-455, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-280344
ABSTRACT
Aleutian mink disease parvovirus (AMDV) causes a persistent infection associated with immune complex disease, hypergammaglobulinemia, and high levels of antiviral antibodies. Despite the presence of an antibody, the virus is not cleared in vivo. Pre-existing antibodies may enhance viral infections, by Fc-receptor-mediated antibody-dependent enhancement (ADE), but the mechanism that underlies ADE has not been fully defined. Three models have been proposed, including (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion. In addition, the role of cytokine IL-6 in ADE mediated disease development is discussed, to facilitate a better understanding of the pathogenesis of AMDV infection, as well as give insights into rational vaccine design approaches.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Aleutian Mink Disease Virus
/
Antibody-Dependent Enhancement
/
Aleutian Mink Disease
/
Allergy and Immunology
/
Genetics
/
Mink
/
Antibodies, Viral
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2014
Type:
Article
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