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A Novel Biomarker of Coronary Atherosclerosis: Serum DKK1 Concentration Correlates with Coronary Artery Calcification and Atherosclerotic Plaques
Journal of Korean Medical Science ; : 1178-1184, 2011.
Article in English | WPRIM | ID: wpr-28042
ABSTRACT
DKK1 modulates Wnt signaling, which is involved in the atherosclerosis. However, no data exist regarding the usefulness of measuring serum DKK1 concentration in predicting coronary atherosclerosis. A total of 270 consecutive patients (62.8 +/- 11.2 yr; 70% male) were included. A contrast-enhanced 64-slice coronary MDCT was performed to identify the presence of atherosclerotic plaques. Agatston calcium scores (CS) were calculated to quantify the coronary artery calcification (CAC). DKK1 concentrations were measured by enzyme-linked immunosorbent assay. For each subsequent DKK1 quartile, there was a significant increase in CAC (P = 0.004) and the number of segments with coronary atherosclerosis (P or = 68.6 pg/mL demonstrated coronary atherosclerotic plaques even when they had low CS. Serum DKK1 concentrations correlate with the coronary atherosclerosis and play an independent role in predicting the presence of coronary atherosclerosis.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Severity of Illness Index / Coronary Artery Disease / Calcinosis / Biomarkers / Tomography, X-Ray Computed / Odds Ratio / Predictive Value of Tests / Risk Factors / Intercellular Signaling Peptides and Proteins / Plaque, Atherosclerotic Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Severity of Illness Index / Coronary Artery Disease / Calcinosis / Biomarkers / Tomography, X-Ray Computed / Odds Ratio / Predictive Value of Tests / Risk Factors / Intercellular Signaling Peptides and Proteins / Plaque, Atherosclerotic Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article