Clinical observation and long-term follow-up of benign infantile epilepsy / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 14-16, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-280519
ABSTRACT
<p><b>OBJECTIVE</b>To investigate clinical characteristics, EEG changes and therapeutic response of benign infantile epilepsy and to study the early diagnostic methods.</p><p><b>METHODS</b>Clinical observation and Video-EEG monitoring were carried out in babies with convulsions at 3 - 24 months of age. In these children, febrile convulsion, symptomatic epilepsies and developmental abnormalities were excluded, and the therapeutic effect and long-term outcome were followed up.</p><p><b>RESULTS</b>Forty-two babies were diagnosed to have benign infantile epilepsy by two-year follow-up. Three of them had familial history of benign infantile convulsions. Nineteen percent had mild diarrhea during the onset of convulsions, cluster seizures occurred during a short period in 67% of cases and no status epilepticus occurred. Video-EEG monitoring confirmed seizures originating from temporal, occipital or multifocal areas separately in 3 patients with partial seizures. Interictal EEG background was normal and there were Rolandic small spikes during sleep in 24% of patients. Thirty-nine patients were treated with single antiepileptic drugs and the mean treatment course was 9 months. Three cases did not take medicine. All the patients were seizure free within a year.</p><p><b>CONCLUSION</b>Benign infantile epilepsy should be considered when the following characteristics occur in early stage of the disease (1) convulsions occurring between 3 to 12 month of age and not later than 24 months of age with or without familial history of benign infantile convulsion; (2) normal psychomotor development before and after convulsion occurs; (3) no evoked factors or only mild diarrhea; (4) majority of cases have partial seizures, or secondary generalized seizures. There are often cluster convulsions during the onset stage, but no status epilepticus; (5) normal EEG background and there may be Rolandic small spikes during sleep; (6) normal neuroimaging.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Follow-Up Studies
/
Treatment Outcome
/
Epilepsies, Myoclonic
/
Therapeutic Uses
/
Diagnosis
/
Diagnosis, Differential
/
Drug Therapy
/
Electroencephalography
/
Anticonvulsants
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pediatrics
Year:
2003
Type:
Article
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