Interregulation of VEGF/R endostatin and MMP in the angiogenesis of hematologic malignancies--review / 中国实验血液学杂志

ABSTRACT

Some kinds of angiogenic correlation factors, e.g. VEGF/R, MMP, endo statin, are relative to the process of hematologic malignancies. The mechanisms of adjusting themselves and controlling mutually have been hot points of the academic research in last few years. Although the rapid progress has been made in studies of this field, it is still hard to come into a systematic theory now. This article introduces the last progress in the field of positive and negative regulatory factors of VEGF/R system in the angiogenesis of hematologic malignancies, the regulation of MMP and its relation with VEGF/R, the regulation of ES and its relation with VEGF/R and MMP.