Study of biological safety of scaffold material with heterologous deproteinized bone / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 234-237, 2006.
Article
in English
| WPRIM
| ID: wpr-280905
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications.</p><p><b>METHODS</b>Deproteinized bone (10 mm) and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test.</p><p><b>RESULTS</b>No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramuscular implantation and cytotoxity were observed.</p><p><b>CONCLUSIONS</b>The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation, Heterologous
/
Cytotoxicity Tests, Immunologic
/
Bone Transplantation
/
Tissue Engineering
/
Hemolysis
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2006
Type:
Article
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