Progress in the studies on the relationship between the polymorphism of P22phox gene and coronary heart disease / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 105-104, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-280954
ABSTRACT
Reactive oxygen species (ROS) are thought to contribute to the progression of cardiovascular disease (CVD). At present, it has been known that the NADH/NADPH oxidase system is the major source of superoxide in the vascular system. Cytochrome b-245 (P22phox), which is a critical component of NADH/NADPH oxidase, plays an important role in electron transport and producing the superoxide anion. It is considerable to take attention to whether the polymorphism of P22phox gene is associated with a risk of coronary heart disease (CHD). To distinguish the relationship between them will be beneficial to elucidate the genetic mechanisms of CHD, and develop a new genetic marker to provide theoretical base for the prevention and cure of CHD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Membrane Transport Proteins
/
Phosphoproteins
/
Polymorphism, Genetic
/
Genetic Markers
/
Risk Factors
/
NADPH Oxidases
/
Coronary Disease
/
Genetics
/
NADPH Dehydrogenase
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2002
Type:
Article
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