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Inhibitory effects of lovastatin on the proliferation and cell cycle phase of cultured human glomerular mesangial cells in vitro / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 63-66, 2002.
Article in Chinese | WPRIM | ID: wpr-280964
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects and mechanism of lovastatin on cell cycle phase and proliferation of cultured human glomerular mesangial cells in vitro.</p><p><b>METHODS</b>HMC proliferation was determined by 3H-Thymidine incorporation. HMC cell cycle was measured by flow cytometric analysis.</p><p><b>RESULTS</b>Lovastatin was found to inhibit HMC proliferation in a dose-dependent manner. Flow cytometric analysis demonstrated that lovstatin induced G1/S transition arrest. Concomitant addition of mevalonate or farnesol restored all the inhibitory effect of lovstatin on HMC.</p><p><b>CONCLUSION</b>Lovastatin is a HMC proliferation inhibitor. It provides an experimental evidence for re-evaluate renal protective effect of HRI, which has already been widely used in clinical treatment.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Lovastatin / Kinetics / Cell Cycle / Cell Division / Cells, Cultured / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Cell Biology / Dose-Response Relationship, Drug / Flow Cytometry Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Lovastatin / Kinetics / Cell Cycle / Cell Division / Cells, Cultured / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Cell Biology / Dose-Response Relationship, Drug / Flow Cytometry Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2002 Type: Article