Optimization of Glycyrrhiza flavonoid and ferulic acid cream by reflect-line orthogonal simplex method / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To optimize the formula of Glycyrrhiza flavonoid and ferulic acid cream and set up its quality control parameters.</p><p><b>METHOD</b>Reflect-line orthogonal simplex method was used to optimize the main factors such as amount of Myrj52-glyceryl monostearate and dimethicone, based on the appearance, spreadability and stability of the cream.</p><p><b>RESULT</b>9.0% Myrj52-glyceryl monostearate (32) and 2.5% dimethicone were chosen in prescription. The prepared cream presented a good stability after being placed 24 h at 5 degrees C, 25 degrees C and 37 degrees C respectively,and its spreadability suited with the property of semi-fluid cream.</p><p><b>CONCLUSION</b>[corrected] The formula of Glycyrrhiza flavonoid and ferulic acid cream is suitable, and its quality is stable. The reflect-line orthogonal simplex method is suitable for the formula optimization of cream.</p>