Clinical evaluation of high-risk HPV detection by hybrid capture II in screening cervical intraepithelial neoplasma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 395-398, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-281189
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the value of high-risk HPV (hrHPV) detection by Hybrid Capture II (HC2) in screening cervical intraepithelial neoplasm (CIN).</p><p><b>METHODS</b>Totally 723 patients who had received a dual screening with thinprep cytologic test (TCT) and HC2 in our department were analyzed retrospectively. Among them, 350 patients received a triple examination with TCT, HC2, and colposcopic biopsy.</p><p><b>RESULTS</b>Among the 723 patients, the incidences of hrHPV infection with atypical squamous cell (ASC), low squamous intraepithelial lesion, and high squamous intraepithelial lesion were 70.7% (94/133), 88.9% (249/280), and 90.9% (90/99), respectively, significantly higher than 55.5% (117/211), the incidence of hrHPV infection with normal cytological results (P = 0.005, P < 0.001, P < 0.001, respectively). Among 350 cases who were received triple examination, the incidence of hrHPV infection with cervical intraepithelial neoplasia (CIN) 1 and CIN 2 were 88.9% (72/81) and 96.3% (52/54), significantly higher than 77.7% (153/197), the incidence of hrHPV infection with normal pathological results (P = 0.03, P = 0.002); The incidence of hrHPV infection with CIN 3 and squamous cancer were 91.7% (11/12) and 100.0% (6/6), also higher than normal cases. Among these 350 cases, the incidence of hrHPV infection with ASC was 79.3% (69/87). The incidence of CIN 2-3 with ASC and hrHPV infection was 38.0%, significantly higher than the incidence of CIN 2-3 with ASC and without hrHPV infection (5.9%) (P = 0.04).</p><p><b>CONCLUSION</b>hrHPV infection has a close relation with CIN, and the incidence of hrHPV infection increases along with the severity of CIN.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Virology
/
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
Cervix Uteri
/
Epidemiology
/
Papillomavirus Infections
/
Human papillomavirus 16
/
Human papillomavirus 18
/
Methods
Type of study:
Diagnostic study
/
Etiology study
/
Screening study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2006
Type:
Article
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