Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 368-371, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-281196
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the susceptibility genes of a Parkinson's Disease (PD) family.</p><p><b>METHODS</b>The blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.</p><p><b>RESULTS</b>We studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.</p><p><b>CONCLUSION</b>These 9 genes are not the susceptibility genes of PD in this family.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Pedigree
/
China
/
Microsatellite Repeats
/
Genetic Predisposition to Disease
/
Genetics
/
Genotype
/
Genetic Linkage
Limits:
Adult
/
Aged
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS