Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 240-243, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-281224
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese.</p><p><b>METHOD</b>Polymerase chain reaction sequence-based typing (PCRSBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese.</p><p><b>RESULTS</b>A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%) , B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%).</p><p><b>CONCLUSION</b>The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spondylitis, Ankylosing
/
HLA-B27 Antigen
/
Polymerase Chain Reaction
/
Classification
/
Sequence Analysis, DNA
/
Genetic Predisposition to Disease
/
Asian People
/
Gene Frequency
/
Genetics
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2006
Type:
Article
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