Linkage analysis of the polymorphism at D17S1878 site with essential hypertension / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 129-133, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-281246
ABSTRACT
<p><b>OBJECTIVE</b>To explore the linkage of the polymorphism at D17S1878 site with susceptible gene of essential hypertension.</p><p><b>METHODS</b>Forty-five pedigrees from the high prevalence region of the hypertension were collected. The polymorphism of D17S1878 site was genotyped with genetic analyzer and gene-scan software. Discordant sib pair analysis and affected sib pair analysis were used in linkage analysis.</p><p><b>RESULTS</b>There were significant differences in the age, male, alcohol-consuming, over-salt intake, average systolic pressure, average diastolic pressure, waist-to-hip-ratio, total cholesterol, high-density lipoprotein, and low density lipoprotein between the hypertensive sib and the normotensive sib (P < 0.05). There were eleven alleles at D17S1878 site, and the allele frequency was significantly different between the hypertensive and normotensive sibs (P < 0.05). Forty-three pedigrees were analyzed with affected sib pair analysis (t = 3.05, P < 0.05).</p><p><b>CONCLUSION</b>The polymorphism of D17S1878 may be linked with susceptible genes of essential hypertension.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Polymorphism, Genetic
/
Case-Control Studies
/
Polymerase Chain Reaction
/
Microsatellite Repeats
/
Genetic Predisposition to Disease
/
Potassium Channels, Inwardly Rectifying
/
Genetics
/
Genotype
/
Hypertension
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS