Expression of hepatocyte growth factor and its receptor in gastric cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1771-1773, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-281541
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of expression of hepatocyte growth factor (HGF) and its receptor (c-Met) in gastric cancer.</p><p><b>METHODS</b>The expression of HGF and c-Met was detected with SABC immunohistochemistry in 44 specimens of gastric cancer, 20 chronic superficial gastritis, 10 chronic atrophic gastritis and 16 gastric ulcer tissues.</p><p><b>RESULTS</b>No positive expression of HGF/c-Met was found in the chronic superficial gastritis specimens. The positivity rates of HGF in the gastric cancer was 72.7% (32/44), significantly higher than that in chronic atrophic gastritis [20% (2/10), P<0.005] and gastric ulcer [37.5% (6/16). P<0.025]. The positivity rates of c-Met in gastric cancer [77.3% (34/44)] was also significantly higher than that in chronic atrophic gastritis [40% (4/10), P<0.05] and gastric ulcer [37.5% (6/16), P<0.025].</p><p><b>CONCLUSION</b>Co-expression of HGF and c-Met in gastric cancer may promote the progression of the malignancy, and also opens a new pathway for the therapy of gastric cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
Hepatocyte Growth Factor
/
Proto-Oncogene Proteins c-met
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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