Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1731-1733, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-281550
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between the expressions of galectin-3 and E-cadherin and lymph node metastasis of colon cancer.</p><p><b>METHODS</b>Immunohistochemistry was employed to examine the expressions of E-cadherin and galectin-3 in 37 colon cancer samples, among which 21 samples underwent RT-PCR for E-cadherin and galectin-3 mRNA expressions. The correlation of E-cadherin and galectin-3 expressions with lymph node metastasis of the tumor was analyzed.</p><p><b>RESULTS</b>The positivity rate of galectin-3 expression was 83.8% (31/37) in these samples. Of the tumor cases with lymph node metastasis, 94.7% (18/19) of the tumors were positive for galectin-3 expression, a rate significantly higher than that in non-metastatic cases. The positivity rate of E-cadherin expression was 59.5% (22/37) in the total cases, and 47.4% (9/19) in the metastatic cases, significantly lower than that in the non-metastatic cases.</p><p><b>CONCLUSION</b>Galectin-3 and E-cadherin expressions are associated with lymph node metastasis of colon cancer and may serve as potential prognostic indicators for colon cancer patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Immunohistochemistry
/
Biomarkers, Tumor
/
Cadherins
/
Colonic Neoplasms
/
Reverse Transcriptase Polymerase Chain Reaction
/
Galectin 3
/
Genetics
/
Lymphatic Metastasis
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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