Effects of 5F from Pteris semipinnate L on growth of human pathological scars in nude mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1677-1680, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-281564
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of 5F from Pteris semipinnate L on the growth of human pathological scar in nude mice.</p><p><b>METHODS</b>5F from Pteris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-beta1 and type I collagen content of the scar tissues were examined after the administration.</p><p><b>RESULTS</b>Administration of 5F significantly reduced the volume of the implanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-beta1 and type I collagen content.</p><p><b>CONCLUSION</b>5F could effectively inhibit the growth of pathological scars in nude mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Plant Extracts
/
Chemistry
/
Cicatrix
/
Collagen Type I
/
Pteris
/
Therapeutic Uses
/
Drug Therapy
/
Transforming Growth Factor beta1
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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