Comparative study on pharmacokinetics of tetramethylpyrazine, ferulic acid and their compatibility / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 900-903, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-281690
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of tetramethylpyrazine (TMP), ferulic acid and their compatibility.</p><p><b>METHOD</b>Twenty-four Sprague-Dawley rats were randomly divided into 3 groups TMP 20 mg x kg(-1), ferulic acid 20 mg x kg(-1) and TMP 20 mg x kg(-1) + ferulic acid 20 mg x kg(-1). All the rats were given intragastric administration then blood samples were obtained from fossa orbitalis at several time points. All the plasmas concentrations were analyzed by HPLC method and the data were treated by DAS 2.0 program.</p><p><b>RESULT</b>The main pharmacokinetics parameters of TMP 20 mg x kg(-1) group, ferulic acid 20 mg x kg(-1) and TMP 20 mg x kg(-1) + ferulic acid 20 mg x kg(-1) were as follows t(max) 0.5 h, t1/2 0.856 h,MRT 1.321 h, AUC 5.112 microg x h(-1) x L(-1), C(max) 2.834 microg x L(-1); t(max) 0.083 h, t1/2 1.024 h, MRT 1.324 h, AUC 1.581 microg x h(-1) x L(-1), C(max) 1.492 microg x L(-1); t(max) 0.583 h, t1/2 37.901 h, MRT 3.798 h, AUC 4.097 microg x h(-1) x L(-1), C(max)1.571 microg x L(-1); t(max) 0.6 h, t1/2 7.860 h, MRT 2.894 h, AUC 1.984 microg x h(-1) x L(-1), C(max) 1.03 microg x L(-1), respectively.</p><p><b>CONCLUSION</b>The experiments suggested that the compatibility of TMP and ferulic acid had interaction in pharmacokinetics; all the t1/2 and MRT were prolonged and had the effect of lente liberates.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrazines
/
Calibration
/
Pharmacokinetics
/
Linear Models
/
Reproducibility of Results
/
Rats, Sprague-Dawley
/
Area Under Curve
/
Coumaric Acids
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
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