Detection of Epstein-Barr virus in T cell lymphoma and clinicopathologic analysis / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 229-233, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-281771
ABSTRACT
<p><b>BACKGROUND</b>To study the relationship of Epstein-Barr virus (EBV) and T cell lymphoma.</p><p><b>METHODS</b>Sixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).</p><p><b>RESULTS</b>EBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma, but in none of seven cases of precursor T lymphoblastic lymphoma. The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas. By Revised European-American Lymphoma(REAL) classification, EBERs were detected in 2/2 angioimmuno-blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma, unspecified (51.9%). The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal (P less than 0.01) there was no significant correlation with the sex, age and clinical stage.</p><p><b>CONCLUSIONS</b>This study indicated that high incidence of EBV was observed in peripheral T cell lymphoma, with predilection for angiocentric lymphoma and extranodal presentation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Virology
/
DNA, Viral
/
Tumor Cells, Cultured
/
Lymphoma, T-Cell
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
/
Genetics
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2003
Type:
Article
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