Detection of Borna disease virus-p24 specific antibody in the sera of schizophrenic patients of China by means of Western-blot / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 85-87, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-281847
ABSTRACT
<p><b>BACKGROUND</b>To investigate whether Borna disease virus (BDV) infection is related to the schizophrenic patients from China.</p><p><b>METHODS</b>A reliable Western-blot method for detection of BDV-p24 antibody was established by adjusting the reaction conditions of BDV-p24 recombinant protein and specific antibodies. The sera of schizophrenic patients and normal controls from Heilongjiang Province were screened for specific BDV-p24 antibody by this method, and the BDV-p24 antibody positive sera were confirmed by the Western-blot method with sera-GST protein absorption.</p><p><b>RESULTS</b>Ten of 116 (8.6%) schizophrenic patients were found to be positive for BDV-p24 specific antibody, while no BDV-p24 specific antibody was found in sera of normal controls.</p><p><b>CONCLUSIONS</b>The results demonstrate that the Borna disease virus infection also exists in China, and the infection is possibly associated with schizophrenia in some way.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Viral Proteins
/
Virology
/
Blood
/
Borna disease virus
/
Blotting, Western
/
Allergy and Immunology
/
Antibodies, Viral
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS