Phosphorylated modification of genistein and their interaction with lysozyme / 药学学报
Acta Pharmaceutica Sinica
;
(12): 396-400, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-281886
ABSTRACT
A series of genistein's phosphates were synthesized through a simplified Atherton-Todd reaction and the structures of the phosphates were determined by electrospray ionization mass spectrometry (ESI-MS) and NMR. In case of monophosporyl derivatives, NMR spectra show that substitutions occur at the 7-position of genistein but not at its 4' and 5-position. Moreover, the non-covalent complexes of lysozyme with the four new genistein phosphates were detected by ESI-MS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Magnetic Resonance Spectroscopy
/
Muramidase
/
Chemistry
/
Genistein
/
Spectrometry, Mass, Electrospray Ionization
/
Protein Interaction Mapping
/
Drug Interactions
/
Metabolism
/
Methods
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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