Effect of griffithin on anticancer activity and apoptosis of cancer cells in vitro / 药学学报
Acta Pharmaceutica Sinica
;
(12): 104-107, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-281917
ABSTRACT
To study the anticancer activity of griffithin from Streptocaulon griffithii Hook. f. and its effect on apoptosis of cancer cells in vitro, the inhibitory effect of griffithin on cell proliferation was studied by MTT assay, the cell apoptosis was observed by AO/EB double decoration assay and flow cytometry. Griffithin exhibited high anticancer activity on four human cancer cell lines, with IC50 ranged from 0.17 - 0.43 microg x mL(-1). Griffithin also induced apoptosis of PC-3 cells. Griffithin had anticancer activity and induced apoptosis of cancer cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Drugs, Chinese Herbal
/
Cardenolides
/
Molecular Structure
/
Cell Cycle
/
Cell Survival
/
Chemistry
/
Apoptosis
/
Plant Roots
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2007
Type:
Article
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