Rituximab combined with second line regimens for treatment of seven relapsed and refractory Hodgkin lymphoma patients / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 578-582, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-281978
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and safety of Rituximab combined with second line regimen for treatment of relapsed and refractory Hodgkin lymphoma.</p><p><b>METHODS</b>Seven patients with relapsed and refractory Hodgkin lymphoma were treated with Rituximab combined with second line regimen. Among them, two patients were treated with R-GDP (E) [rituximab, gemcitabine, cisplatin, dexamethasone (etoposide)] regimen, another two patients with R-IGVP (rituximab, ifosfamide, gemcitabine, vinorelbine, prednisone)regimen, and the left three patients with R-BEACOPP (rituximab, bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone)regimen. The efficacy and safety were evaluated during and after chemotherapy.</p><p><b>RESULTS</b>There're three male and four female patients, whose median age was 21 years (range 12-36 years) old. One patient was diagnosed as nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and the other six patients as classical HL (four nodular sclerosis HL, one lymphocyte-rich classical HL and one hmixed cellularity HL). The median cycles of salvage therapy were 4(1-4), and the median follow-up was 29 months (24-58 months). Among these 7 patients, the complete remission was observed in 4 patients, stable disease in 2 patients, but one patient died during salvage therapy. The two-year survival rates were 85.7% and the major toxic effects were bone marrow suppression.</p><p><b>CONCLUSION</b>These results indicate that the Rituximab combined with second line regimen is an effective therapy for relapsed and refractory Hodgkin lymphoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Procarbazine
/
Vinblastine
/
Vincristine
/
Bleomycin
/
Remission Induction
/
Dexamethasone
/
Hodgkin Disease
/
Prednisone
/
Antineoplastic Combined Chemotherapy Protocols
/
Doxorubicin
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2015
Type:
Article
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