Clinical and biological characteristics of non-IgM lymphoplasmacytic lymphoma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 493-496, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-282000
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical and biological characteristics of Non-IgM-secreting lymphoplasmacytic lymphoma (LPL) and draw the differences between non-IgM LPL and Waldenström macroglobulinemia (WM).</p><p><b>METHODS</b>Records of 13 patients with non-IgM LPL were retrospectively analyzed between January 2000 and December 2013. The cytogenetic aberrations were detected by fluorescence in situ hybridisation (FISH).</p><p><b>RESULTS</b>In the cohort, 7 males and 6 females with a median age of 63 years (range 43 to 74), two patients were IgA secreting, 6 with IgG secreting and 5 patients without monoclonal globulin. The major complaint at diagnosis included anemia associated symptom (53.8%), mucocutaneous hemorrhage and superficial lymphadenopathy (15.4%). Eight patients had B symptom at diagnosis. All of the 13 patients had bone marrow involvement and anemia, and 10 patients had 2 or 3 lineage cytopenia. In 5 patients with available immunophenotypic data, all expressed CD19, CD20, CD22 and CD25, but missed the expression of CD10, CD103 and CD38. Two cases had CD5 or sIgM positive alone. Another 2 patients were CD23 or CD11c positive and 3 patients were FMC7 positive. Cytogenetic aberrations had been detected by FISH in 7 patients, but only two (28.6%) patients had aberrations with del(6q).</p><p><b>CONCLUSION</b>The clinical and biological characteristics had no significantly difference between non-IgM LPL and WM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin M
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Antigens, CD
/
Retrospective Studies
/
Chromosome Aberrations
/
Waldenstrom Macroglobulinemia
/
In Situ Hybridization, Fluorescence
/
Integrin alpha Chains
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2015
Type:
Article
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