Genetic polymorphisms of CYP2D6 in Chinese mainland / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1780-1784, 2002.
Article
in English
| WPRIM
| ID: wpr-282091
ABSTRACT
<p><b>OBJECTIVE</b>To observe the significant differences in the frequencies of the cytochrome P450 2D6 (CYP2D6) alleles in Chinese popoulations.</p><p><b>METHODS</b>Tetra-primer polymerase chain reaction (PCR), allele specific amplification (ASA) PCR and multiplex long PCR were developed to detect the CYP2D6 alleles * 2, * 3, * 4, * 5, * 6, * 8, * 10 and * 14 in 223 subjects from Chinese mainland.</p><p><b>RESULTS</b>The CYP2D6 * 5 allele was the most frequent poor metabolizer (PM) allele in Chinese (7.2%), followed by CYP2D6 * 14 (2.0%) which was only detected in orientals. There was only 0.2% CYP2D6 * 4, and no CYP2D6 * 3, * 6 and * 8 were detected. In contrast to the Caucasians, the most frequent allele in Chinese was the * 10 allele with a frequency of 51.6%.</p><p><b>CONCLUSION</b>The frequencies of PM alleles, CYP2D6 * 5 and CYP2D6 * 14, were higher; but the frequency of CYP2D6 * 10 was lower in mainland Chinese population than that in other orientals.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
China
/
Cytochrome P-450 CYP2D6
/
Alleles
/
Genetics
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Journal
Year:
2002
Type:
Article
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