A preliminary clinical application of sICAM-1 RIA in three kinds of thyroid disease / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1552-1555, 2002.
Article
in English
| WPRIM
| ID: wpr-282142
ABSTRACT
<p><b>OBJECTIVE</b>To examine serum levels of sICAM-1 from normal controls and patients with thyroid diseases (simple goitre, Graves' disease or Hashimoto's thyroiditis) with (125)I-sICAM-1 RIA established in our lab.</p><p><b>METHODS</b>Using (125)I-sICAM-1 RIA, serum sICAM-1 levels of 400 healthy individuals as the normal group and 1020 patients with simple goitre (SG), Graves' disease (GD) or Hashimoto's thyroiditis (HT) were examined for a comporative chinical study.</p><p><b>RESULTS</b>The serum level of sICAM-1 (x +/- s) in the normal group was 168.43 +/- 36.23 micro g/L. There was no significant difference between the normal and SG groups (P > 0.05), whereas the serum levels of sICAM-1 in autoimmune thyroid diseases (GD or HT) were higher than those in the normal or SG groups (P < 0.05, respectively). After GD patients received one of three medical treatments, their serum sICAM-1 levels decreased (P < 0.05). After GD patients were treated and their thyroid function decreased to normal, their serum sICAM-1 levels were lower than those in relapsed GD patients (P < 0.05).</p><p><b>CONCLUSIONS</b>sICAM-1 RIA can be used to examine autoimmune thyroid diseases. Serum levels of sICAM-1 can be used as a parameter in diagnosing autoimmune thyroid disease and in evaluating the effects of therapy, drug administration or relapse in GD.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Thyroiditis, Autoimmune
/
Radioimmunoassay
/
Graves Disease
/
Intercellular Adhesion Molecule-1
/
Diagnosis
/
Goiter
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2002
Type:
Article
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